If A Sister Has Already Tested Negative For A Bone Marrow Transplant, Can She Become Positive 13 Yrs Later ?
Posted by: Alan in Obstructive Sleep Apnea, tags: Already, Become, Bone, Later, Marrow, Negative, Positive, Sister, Tested, Transplant
Has the technology changed or has there been new medical breakthroughs that would permit a sibling who was initially tested negative for compatibility for bone marrow 13 years ago, be able to test positive today in 2008 and provide such bone marrow?
Also, if the sibling has already tested negative and he/she decides to redo the test than mathematically speaking shouldn’t the test yeild the same result (i.e.: test negative)?
Moreover, if someone has sleep apnea, notably obstructive sleep apnea (OSA) in its severest form, and he/she wishes to donate his/her bone marrow (providing that the blood test is positive), how would this person be anaesthetised? Does this person need a sleep apnea machine, hence CPAP, attached to them during surgery? Is a surgeon able to perform surgery on this person? If so, how would he/she go about it given the sensitivity and gravity of this situation?
If someone has DVT, blood clotting and takes cumadin for life, can this person be tested ?
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December 16th, 2009 at 8:06 pm
No, the sibling is not going to just suddenly match.
As far as pulling the bone marrow, that method is rarely used today. Today in most cases the stem cells are collected from the peripheral blood. THe stem cells are a type of white blood cell and they are collected using a aphersis machine – this is the same thing as at the plasma center or some red cross donations. You have a couple needles in you for a few hours, but it doesnt hurt and there is no need to be anesthesized.
But, the person is not going to suddenly match anyways, so it doesnt matter.
Has the person tried the Marrow registry? Cord blood registry? This would be handled by the hemotologist and they go through the National Marrow Donor’s Program registry which is also hooked into several international registries.
EDIT: AR S below me is a lil confused. Yes, today they can use less than perfect match, and even less if cord blood is used. The proceedure he is talking about where they dont kill all the marrow is called a ‘mini transplant’, but thats not because the donor is less of a match, they actually need to be closer to perfect match. The chimera thing is true of all bone marrow transplant patients, and honestly the reciepient of any organ, and a lot of people by nature. http://en.wikipedia.org/wiki/Chimera_%28…
December 16th, 2009 at 11:08 pm
There are now some experimental transplantation in which they need just partial genetic match.
They do not kill the receiver’s blood marrow, just suppress it for sufficient time so that some donor cells will join the blood marrow – so effectively the person becomes a chimeric (having a mix of two types of cells from different genetic origins). And the donor cells start eliminating the cancer without hurting the host’s normal cells. These treatments are much milder and less riskier than bone marrow transplantation.
December 17th, 2009 at 1:13 am
You should be asking a Doctor these questions. Seems some one has a very serious situation. I hope you find your answers.
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